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As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays. All these results indicate that the change in the expression of the HMGCR protein during the cholesterol and lovastatin feeding is a result of sterol-mediated modulation of its degradation. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the p Search external sites for HMGCR Gene name. HMGCR : Synonyms.

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NXP2-antikroppar. TIF1γ-antikroppar. SRP-antikroppar. HMGCR-antikroppar. cN1A-antikroppar.

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Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. HMG Coenzyme A reductase (Hmgcr) encodes the rate-controlling enzyme of the mevalonate pathway that produces isoprenoids.

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Created with Gene Aliases: HMGCR; LDLCQ3. 31 Jan 2011 3-Hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase gene (Hmgcr) is a susceptibility gene for essential hypertension.

The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers. HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase (human) HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial Hyperlipidemia and Sitosterolemia.
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HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

In paper II, we studied the interplay between tumor-specific HMGCR levels, preoperative statin use, and the multi-drug resistance gene (MDR1/ABCB1) in breast  MEDICAL AND HEALTH SCIENCES; Breast cancer; Statins; HMGCR; Cyclin D1; p27; Clinical trial; Gene expressionprofiling; cholesterol-lowering medication  kologisk blockering av HMGCR med statiner har som bekant visats sänka LDL-kolesterolet med klinisk användning, men eftersom bestämning av dessa gene-. MSc minor thesis project, Obesity-linked gene TfAP-2 and Twz of Drosophila Stipend Project, Loss of Hydroxymethylglutaryl-CoA reductase,(Hmgcr) in the  vid anti-HMGCR-positiv myopati. Orsaken till IMNM är okänd med positiva anti-HMGCR antikroppar rentiation-associated gene 5 is a major autoantigen in  av A Miettinen — differentiation associated gene 5). SAE-antikroppar. NXP2-antikroppar. TIF1γ-antikroppar. SRP-antikroppar.
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In  26 Mar 2009 To study the role of genetic variation in the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR) gene in polycystic ovary  HUGO Gene Nomenclature Committee (HGNC) approved gene symbol report for HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) reductase (HMGCR) gene, the rate-limiting enzyme in cho- lesterol biosynthesis, and the target of LDL-C lowering statin drugs. During the preparation of this  15 Oct 2008 and HMG-CoA Reductase Genes by Human ACBP Cholesterol • Gene regulation • HNF-4α • Promoter HMGCS1 and HMGCR gene. Gene Snapshot. HMG Coenzyme A reductase (Hmgcr) encodes the rate- controlling enzyme of the mevalonate pathway that produces isoprenoids. It is required  10 Products Gene ID: Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback  20 Nov 2017 The low-density lipoprotein cholesterol (LDLC)-lowering allele of a variant in the HMGCR gene that encodes the targeted enzyme in statin  5 Mar 2021 HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial  Species, TM, AA, Chromosomal Location, Gene Symbol, Gene Name, Reference.

Copy Number Determination. HMGCR chr5.
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3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Summary of HMGCR This gene encodes an enzyme that catalyzes the rate limiting step in cholesterol biosynthesis (R). 0 users want this gene increased, 0 users want it decreased The Function of HMGCR Luskey (1987) determined that the human HMGCR gene has several transcriptional start sites that generate relatively short 5-prime UTRs of 73 to 105 nucleotides. As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001).

Body constitution, statin use, and tumor - AVHANDLINGAR.SE

MSc minor thesis project, Obesity-linked gene TfAP-2 and Twz of Drosophila Stipend Project, Loss of Hydroxymethylglutaryl-CoA reductase,(Hmgcr) in the  vid anti-HMGCR-positiv myopati. Orsaken till IMNM är okänd med positiva anti-HMGCR antikroppar rentiation-associated gene 5 is a major autoantigen in  av A Miettinen — differentiation associated gene 5). SAE-antikroppar. NXP2-antikroppar. TIF1γ-antikroppar. SRP-antikroppar.

HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary 2014-11-24 · Luskey (1987) determined that the human HMGCR gene has several transcriptional start sites that generate relatively short 5-prime UTRs of 73 to 105 nucleotides.